2. Signaling Pathways
  3. Neuronal Signaling
  4. Serotonin Transporter

Serotonin Transporter

5-HTT; SERT; SLC6A4

Serotonin Transporter

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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-32126R
    1-Fluoronaphthalene (Standard)
    		Inhibitor
    1-Fluoronaphthalene (Standard) is the analytical standard of 1-Fluoronaphthalene. This product is intended for research and analytical applications. 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake.
    1-Fluoronaphthalene (Standard)
  • HY-W735205
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
    		Control
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride is a metabolite of the selective serotonin reuptake inhibitor (SSRI) Sertraline (HY-B0176A).
    (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
  • HY-W022362
    2-Aminotetralin
    		Agonist
    2-Aminotetralin is a potent and selective serotonin 5-HT1 agonist. 2-Aminotetralin exhibits high affinity (Ki≤25 nM) and at least 50-fold stereoselective preference at 5-HT1A, 5-HT1B, and 5-HT1D receptors.
    2-Aminotetralin
  • HY-138257A
    (R)-Indeloxazine benzenesulfonate
    		Inhibitor
    (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.35 μM and 3.3 μM, respectively. (R)-Indeloxazine benzenesulfonate (AS1069562) possesses curative-like analgesic effect. (R)-Indeloxazine benzenesulfonate (AS1069562) might improve nerve function impairment via the amelioration of neurotrophic support.
    (R)-Indeloxazine benzenesulfonate
  • HY-B0103AR
    Fluvoxamine maleate (Standard)
    		Inhibitor
    Fluvoxamine (maleate) (Standard) is the analytical standard of Fluvoxamine (maleate). This product is intended for research and analytical applications. Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
    Fluvoxamine maleate (Standard)
  • HY-B0478AR
    Trazodone (Standard)
    		Antagonist
    Trazodone (AF-1161 free base) (Standard) is the analytical standard of Trazodone. This product is intended for research and analytical applications. Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). Trazodone has anti-depressant and anti-insomnious activity. Trazodone exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects.
    Trazodone (Standard)
  • HY-B1272R
    Desipramine hydrochloride (Standard)
    		Inhibitor
    Desipramine (hydrochloride) (Standard) is the analytical standard of Desipramine (hydrochloride). This product is intended for research and analytical applications. Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
    Desipramine hydrochloride (Standard)
  • HY-101250R
    Glemanserin (Standard)
    		Antagonist
    Glemanserin (Standard) is the analytical standard of Glemanserin. This product is intended for research and analytical applications. Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively).
    Glemanserin (Standard)
  • HY-W297421
    (S)-Tomoxetine hydrochloride
    		Inhibitor 99.79%
    (S)-Tomoxetine hydrochloride (LY-139602) is an isomer of the norepinephrine reuptake inhibitor LY 139603 (HY-17385) with an inhibition constant (Ki) of 16.8 nM for norepinephrine reuptake.
    (S)-Tomoxetine hydrochloride
  • HY-131527
    Wy-45494 hydrochloride
    		Inhibitor
    Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
    Wy-45494 hydrochloride
  • HY-B1490AR
    Imipramine (Standard)
    		Inhibitor
    Imipramine (Standard) is the analytical standard of Imipramine. This product is intended for research and analytical applications. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects.
    Imipramine (Standard)
  • HY-106397A
    Delucemine hydrochloride
    		Inhibitor
    Delucemine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. Delucemine hydrochloride can be used as an antidepressant.
    Delucemine hydrochloride
  • HY-122272S
    Paroxetine-d4
    		Inhibitor
    Paroxetine-d4 (BRL29060-d4) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches.
    Paroxetine-d<sub>4</sub>
  • HY-B0103AS
    (E)-Fluvoxamine-d4 maleate
    (E)-Fluvoxamine-d4 (maleate) is the deuterium labeled (E)-Fluvoxamine maleate[1].
    (E)-Fluvoxamine-d<sub>4</sub> maleate
  • HY-B0168S
    Milnacipran-d10 hydrochloride
    		Inhibitor
    Milnacipran-d10 (hydrochloride) is the deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).
    Milnacipran-d<sub>10</sub> hydrochloride
  • HY-B0492S
    rel-Paroxetine-d4-1 hydrochloride
    (rac)-(trans)-Paroxetine-d4 (hydrochloride) is the deuterium labeled (rac)-(trans)-Paroxetine hydrochloride.
    rel-Paroxetine-d<sub>4</sub>-1 hydrochloride
  • HY-B0161S
    Duloxetine-d7
    		Inhibitor
    Duloxetine-d7 ((S)-Duloxetine-d7) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
    Duloxetine-d<sub>7</sub>
  • HY-101684A
    Nitroxazepine hydrochloride
    		Inhibitor
    Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
    Nitroxazepine hydrochloride
  • HY-B0196S3
    Venlafaxine-d10
    		Inhibitor
    Venlafaxine-d10 (Wy 45030-d10) is deuterium labeled Venlafaxine. Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.
    Venlafaxine-d<sub>10</sub>
  • HY-135556A
    Norfluoxetine oxalate
    Norfluoxetine oxalate is an active metabolite of Fluoxetine (HY-B0102). Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
    Norfluoxetine oxalate
Cat. No. Product Name / Synonyms Application Reactivity